Answered June 9, 2018. If you experience a worsening of side effects, contact your health care professional. This can affect the rhythm of your heart. The result: too much drug in your body. grapefruit alcohol interaction A 21-year-old female asked: can i safely take phenergan (promethazine) several hours after drinking (like enough to get mildly drunk)? Comprehensive alcohol & food interactions for Viagra (sildenafil). As shown above, grapefruit juice can block the action of these enzymes, increasing the amount of drug in the body and may cause more side effects. Some drugs that treat high blood pressure, such as Procardia and Adalat CC (both nifedipine). Play it safe with prescription drugs. The scientists point out that grapefruit can interfere with the body’s normal way of handling Zocor, leading to unusually high levels of the drug. But it is noteworthy to mention that sugar, like that found in grapefruit juice (a naturally-occurring sugar) slows down the absorption of alcohol into the body’s bloodstream. Laboratory tests suggested a serious muscle breakdown reaction as a result of her cholesterol-lowering medicine. The drug was stopped, and doctors intervened and prevented kidney failure. Grapefruit juice can increase the blood levels and effects of verapamil. Attempting to potentiate the effects of an opioid drug by drinking grapefruit juice can alter the drug’s metabolism. Grapefruit juice, it turns out, can affect some medications. While we would still advise caution on the matter and advise that no one drink grapefruit juice while taking these drugs, due to the fact that there are so many other Grapefruit Juice Drug Interactions, but it would seem, based on a very thorough search and many years of listening to thousands of people who have been negatively affected by the fluoroquinolone drugs, that grapefruit juice … Grapefruit (and its juice) can alter the effects of many drugs, including calcium channel blockers. This tactic seems logical, but it may be misleading. Grapefruit juice alone raised blood levels of felodipine dramatically, leading to adverse effects in some cases. They happened to use grapefruit juice to mask the taste of the alcohol, and discovered unexpectedly high levels of the drug in the blood. Doses that might be considered safe under most cases may become dangerous. Although the alcohol interaction was not very interesting, the experiment did produce unexpected results. In such cases, it is worthwhile to ask the doctor if a medicine that doesn’t react with grapefruit might do the job. Ezetimibe Interactions with Alcohol Ezetimibe interacts with alcohol. Notes for Consumers: Tell your health care provider if you drink grapefruit juice regularly.An interaction between Aripiprazole and Grapefruit juice is possible, but they may be used together. For example, if you drink a lot of grapefruit juice while taking certain statin drugs to lower cholesterol, too much of the drug may stay in your body, increasing your risk for liver and muscle damage that can lead to kidney failure. One whole grapefruit or 200ml of juice is sufficient to cause enough of an increase in the concentrations of active drugs to have an effect on the body, and therefore could cause side effects. Subscribe to receive Consumer Update email notifications. While the alcohol did not affect the amount of the drug circulating in the body, the grapefruit juice greatly increased the levels of the medication. Grapefruit juice increases the drug levels in the blood stream potentially leading to side effects of the drug. This fruit and its juice can dangerously raise blood levels of some antipsychotic drugs such as lurasidone ( Latuda ), quetiapine ( Seroquel ), and ziprasidone ( Geodon ). While you may enjoy the vitamin C-packed nutrients found in grapefruits, eating grapefruit with certain medications can negatively impact your health. “Currently, there is not enough clinical evidence to require Zoloft, Viagra, or Adderall to have a grapefruit juice interaction listed on the drug label,” wrote an FDA representative in an email. The site is secure. They were investigating the effect of alcohol on drug metabolism and used grapefruit juice to disguise the taste of ethanol. Fexofenadine (brand name Allegra) is available as both prescription and OTC to relieve symptoms of seasonal allergies. People still don’t understand why it’s important, how long it lasts and how to avoid problems. ↑ Mohri, Kiminori, and Yoshihiro Uesawa. But grapefruit lovers can still control their cholesterol. Patients who regularly consumed grapefruit juice or alcohol or who were taking drugs known to interact with grapefruit juice were excluded. A 40-year-old German woman was admitted to the hospital complaining of severe weakness in both legs. Pravachol (pravastatin) is unaffected by grapefruit, and so is Zetia, the medicine prescribed for the German woman after she left the hospital. This chance discovery has led to a whole new appreciation of how foods can … View abstract. Anyone who would like copies, please send $3 in check or money order with a long (no. If you must avoid grapefruit juice with your medicine, check the labels of fruit juices or drinks flavored with fruit juice to see whether they are made with grapefruit juice. The ability of grapefruit to increase the plasma concentrations of some drugs was accidentally discovered when grapefruit juice was used as a blinding agent in a drug interaction study of felodipine and alcohol (10). You can also check your Patient Medication Guide that accompanies your prescription, and your pharmacist may include a label on your bottle warning you of an interaction. Statin drugs, also known as HMG-CoA reductase inhibitors, work by blocking the enzyme that your body needs to produce cholesterol. Here are examples of some types of drugs that grapefruit juice can cause problems with (interact): Grapefruit juice does not affect all the drugs in the categories above. The severity of the interaction can be different depending on the person, the drug, and the amount of grapefruit juice you drink. Box 52027, Durham, NC 27717-2027. Join our daily email newsletter with breaking health news, prescription drug information, home remedies AND you'll get a copy of our brand new full-length health guide — for FREE! Some antihistamines, such as Allegra (fexofenadine). Grapefruit. Talk to your doctor, pharmacist or other health care provider and read any information provided with your prescription or OTC drug to find out: With most drugs that interact with grapefruit juice, “the juice lets more of the drug enter the blood,” Huang says. Some corticosteroids that treat Crohn’s disease or ulcerative colitis, such as Entocort EC and Uceris (both budesonide). Additional grapefruit juice drug interactions, and interactions with other juices, can be researched in the Drug Interaction Checker. You should avoid consuming grapefruits and grapefruit juice while taking amiodarone. Grapefruit juice can cause problems with these enzymes and transporters, causing too much or too little drug in the body. They recommend that patients on Zocor not eat grapefruit. Some people have a lot of enzymes and others just a little. Grapefruit juice was used as a vehicle to mask the taste of the alcohol. Want to get drunk? As a result, less of the drug enters the blood and the drug may not work as well, Huang says. What other fruits or juices may also affect your drug in a similar way to grapefruit juice. This food and drug interaction can be a concern, says Shiew Mei Huang, PhD, of the U.S. Food and Drug Administration. Am J Clin Nutr 2006;83(5):1097-1105. 5 (2005): 494-497. Grapefruit juice can affect how well some medicines work, and it may cause dangerous side effects. Grapefruit juice does not affect all the drugs in the categories above. 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